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Kibron Delta-8: high throughput critical micelle concentration
Kibron Delta-8 represents a true breakthrough, making high throughput screening possible in surface chemistry, from critical micelle concentration measurement to advanced drug discovery.
For pharmaceutical companies Delta-8 serves as the platform for Kibron PLDscreen, a unique assay predicting phospholipidosis with unprecedented accuracy, as well as for physicochemical profiling (QSAR) of compounds, providing key parameters such as Kaw, TSA, critical micelle concentration and surface pKa.
For chemical industries, including surfactant/detergent suppliers and users, Delta-8 represents a revolutionary platform for cost-efficient product optimization. High throughput screening of critical micelle concentration and surface tension can be made more than 100 times faster compared to conventional methods, with minimal sample consumption.
As high content screening of molecules has become a standard procedure within the industry, it has started to undergo rapid evolution also into the academic sector. HTS allows discovery driven research projects to be tackled on a totally new scale, generating data at unprecedented rate.
The high throughput of Delta-8 opens new exciting possibilities for surface chemistry R&D, allowing comprehensive and truly efficient physicochemical profiling.
In ADME/tox Kibron Delta-8 has already provided novel data and correlations (Study on fraction absorbed). However, this is just the tip of the iceberg. Kibron wants to explore new application areas for Delta-8 and looks actively for collaboration in the this field.
Specification:
| Temperature range | 18–30°C | ||||||||||||||||||||||||||||||
| Measurement volume | 50 μl/well | ||||||||||||||||||||||||||||||
| Surface tension range | 10-100 mN/m | ||||||||||||||||||||||||||||||
| Resolution | 0.01 mN/m | ||||||||||||||||||||||||||||||
| Balance resolution | 0.050 μgrams | ||||||||||||||||||||||||||||||
| Precision | 0.2 mN/m | ||||||||||||||||||||||||||||||
| Method | du Noüy-Padday | ||||||||||||||||||||||||||||||
| Measurement time | (96-well plate) 3 minutes | ||||||||||||||||||||||||||||||
| Probe lifetime | 100 plates | ||||||||||||||||||||||||||||||
| Cleaning of Dyneprobes | DyneClean electric furnace | ||||||||||||||||||||||||||||||
| DyneClean lifetime | 400 platesDynePlate - 96-well plates
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